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Polygenic Risk for Major Depression: Diagnostic Specificity and Developmental Trajectories in an Admixed Youth Cohort

delete2026-07-17
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OA
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M
Marcelo J. A. A. Brañas *
L
Lucas Toshio Ito
M
Marcos S. Croci
A
Ana Beatriz Ravagnani Salto
V
Victoria Fogaça Doretto
M
Marcos Leite Santoro
V
Vanessa Kiyomi Ota
L
Luis Augusto Rohde
G
Giovanni Abrahão Salum
L
Lois W. Choi‐Kain
S
Síntia Belangero
E
Eurı́pedes Constantino Miguel
M
Maurício Scopel Hoffmann
P
Pedro Mário Pan
DOI:10.1016/j.biopsych.2026.07.006delete
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Abstract

Abstract

En 中文
Major Depressive Disorder (MDD) is heritable and polygenic, yet the relative diagnostic specificity, developmental impact, and cross-ancestry generalizability of MDD polygenic risk scores (MDD-PRS) remain unclear.
Keywords:
Major Depressive Disorder
Polygenic Risk Score
Developmental Trajectories
Longitudinal Study
Adolescent Development
Admixed Population
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Journal

Biological Psychiatry cover
Biological Psychiatry
IF:
9
Papers:
1.5W
Citations:
4.0W

Organization

H
harvard medical school
Scholars:
4.6K
Papers: 2.1K
Citations: 2
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