.png){kind=icon}
.png){kind=icon}
Return
Polygonal nucleic acid frame-accelerated nanomachine with dual recognition sites for sensitive sensing of breast cancer metastasis
.png){kind=icon}
PRE
AI
L
X
X
Q
L
Y
B
王
S
DOI：10.1016/j.snb.2026.140674.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• A dual-miRNA electrochemical sensor is developed based on a polygonal nucleic acid frame-driven DNA nanomachine. • The dual detection of miRNA-21 and miRNA-105 is achieved with detection limits at the aM level. • Substrate-free AuPd@CoMOF electrocatalysis eliminates exogenous analytical errors. • Spatial confinement shortens reaction time by 55% and enhances current response by 63%. • The sensor discriminates metastatic from non-metastatic breast cancer cells and matches qRT-PCR in clinical serum.
Journal
IF:
7.7
Papers:
3.3W
Citations:
12.6W
Organization
Cited Papers