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Post-myocardial infarction complications in patients with inflammatory bowel disease: a retrospective cohort study using the National Inpatient Sample (2016-2022)
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DOI：10.1080/14796678.2026.2639403.png)
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Abstract
En 中文
Background: Inflammatory bowel disease (IBD) is associated with systemic inflammation and increased cardiovascular risk, but its impact on in-hospital outcomes after acute myocardial infarction (MI) remains unclear. Methods: We conducted a retrospective cohort study using the National Inpatient Sample (2016-2022) to identify hospitalizations for acute MI and compared outcomes between patients with and without IBD. Multivariate logistic regression was used to evaluate the association between IBD and post-MI complications. Associations were summarized as adjusted odds ratios (aORs) with 95% confidence intervals (CIs). Results: Among 1,456,940 MI hospitalizations, 7,430 had IBD. After adjustment, IBD was associated with higher odds of mortality (aOR 3.32, 95% CI 3.18-3.47; p < 0.0001), left ventricular rupture (aOR 4.46, 95% CI 3.16-6.28; p < 0.0001), left ventricular aneurysm (aOR 1.93, 95% CI 1.61-2.31; p < 0.0001), acute mitral regurgitation (aOR 9.80, 95% CI 6.81-14.10; p < 0.0001), and stent restenosis (aOR 1.16, 95% CI 1.07-1.26; p = 0.0002). IBD was also associated with longer hospital stay (coefficient 2.13 days, 95% CI 2.03-2.23; p < 0.0001) and higher total hospital charges.Conclusion: IBD was associated with worse in-hospital outcomes and higher resource utilization after MI in this nationwide hospitalization-level analysis.
Keywords:
Inflammatory bowel disease
Crohn's disease
ulcerative colitis
myocardial infarction
post-myocardial infarction complications
in-hospital mortality
National Inpatient Sample
healthcare utilization
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