Potential systemic effects of acquired CFTR dysfunction in COPD

Marc Miravitlles

doi:10.1016/j.rmed.2023.107499

Potential systemic effects of acquired CFTR dysfunction in COPD

2024-01-01

6

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Matthias Schoenberger

P

Pablo Altman

DOI：10.1016/j.rmed.2023.107499

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Abstract

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Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, respiratory symptoms, inflammation of the airways, and systemic manifestations of the disease. Genetic susceptibility and environ-mental factors are important in the development of the disease, particularly exposure to cigarette smoke which is the most notable risk factor. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are the cause of cystic fibrosis (CF), which shares several pathophysiological pulmonary features with COPD, including airway obstruction, chronic airway inflammation and bacterial colonization; in addition, both diseases also present systemic defects leading to comorbidities such as pancreatic, gastrointestinal, and bone-related diseases. In patients with COPD, systemic CFTR dysfunction can be acquired by cigarette smoking, inflammation, and infection. This dysfunction is, on average, about half of that found in CF. Herein we review the literature focusing on acquired CFTR dysfunction and the potential role in the pathogenesis of comorbidities associated with COPD and chronic bronchitis.

Keywords:

COPD

Chronic bronchitis

CFTR dysfunction

Multi-organ disease

Cigarette smoke

Icenticaftor

CFTR potentiator

Potential systemic effects of acquired CFTR dysfunction in COPD

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