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Potentiation effects of the positive allosteric modulator PTC-174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons
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DOI：10.1111/bph.70615.png)
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Abstract
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Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC-174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits. We have investigated potentiation by PTC-174 of dopaminergic neuron NMDA responses, where receptors are likely to be GluN1/GluN2B/GluN2D triheteromeric receptors.
Keywords:
dopaminergic neurons
ion channels
neuropharmacology
NMDA receptors
positive allosteric modulator
substantia nigra
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