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PPARα Activation with Fenofibrate Confers Hippocampal Neuroprotection but Lacks Disease-Modifying Efficacy in Chronic Temporal Lobe Epilepsy
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DOI：10.1016/j.neuint.2026.106206.png)
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Abstract
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• Fenofibrate protects hippocampal neurons in chronic temporal lobe epilepsy. • Fenofibrate reduces astrogliosis and amoeboid microglia in hippocampus. • Fenofibrate improves exploratory behavior but not spontaneous seizures. • PPARα activation fails to normalize chronic EEG spectral power. • Neuroprotection does not equate to antiepileptogenic efficacy.
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