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PRCD-associated retinitis pigmentosa in dogs and humans
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DOI：10.1016/j.exer.2026.111045.png)
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Abstract
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• Centripetal progression of ophthalmoscopic changes with preserved cone-rich central retina • Early reduction of ONL thickness along the inferior retina • Reduced scotopic ffERG a-wave in PRCD-affected dogs • Retinitis pigmentosa in PRCD-affected patients can show preserved central retina and constricted visual fields despite widespread peripheral degeneration. • PRCD is expressed in both rods and cones of the canine retina and is absent in dogs with the homozygous C2Y missense mutation.
Keywords:
retinitis pigmentosa
PRCD
inherited retinal diseases
canine model
progressive rod cone degeneration
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