1
Return

Pre-analytical Determinants of Patient Eligibility for Immune Checkpoint Inhibitors Revealed by Quantitative PD-L1 Analysis

delete2026-05-22
delete0
delete
OA
AI
A
Alessandro Gambella *
L
Luca Mastracci
C
Chiara Trambaiolo
L
Luca Guastini
M
Michele Paudice
S
Simona Pigozzi
S
Silvia Bozzano
V
Valentina Angerilli
A
Alessandro Caputo
P
Paola Parente
A
Alessandro Vanoli
M
Matteo Fassan
F
Federica Grillo
DOI:10.1016/j.labinv.2026.106138delete
deleteOriginal
deleteShare
deleteSave
View PDF
Abstract

Abstract

En 中文
The assessment of PD-L1 protein expression is a predictive biomarker for subsequent immune checkpoint inhibitor (ICI)-based therapies. The purpose of this study was to granularly and quantitatively define the impact of pre-analytical variables such as cold ischemia time and tissue block and slide aging on PD-L1 expression evaluation via immunohistochemistry.
Keywords:
false negative
immunohistochemistry
quality control
CD274
clinical trial
computational pathology
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Laboratory Investigation cover
Laboratory Investigation
IF:
4.2
Papers:
5.4K
Citations:
1.1W

Organization

F
foggia university hospital
Scholars:
3
Papers: 3
Citations: 0
I
iov-irccs
Scholars:
30
Papers: 10
Citations: 0
U
University Hospital of Salerno
Scholars:
14
Papers: 9
Citations: 0
U
university of pavia
Scholars:
2.0W
Papers: 1.6W
Citations: 8
I
irccs san martino hospital
Scholars:
11
Papers: 7
Citations: 0
I
irccs azienda ospedaliera metropolitana
Scholars:
77
Papers: 39
Citations: 0
I
Istituto Giannina Gaslini
Scholars:
40
Papers: 14
Citations: 3.4K
U
ulss2 marca trevigiana
Scholars:
21
Papers: 11
Citations: 1
U
university of genoa
Scholars:
2.9W
Papers: 2.2W
Citations: 20
Cited Papers

Cited Papers

Citing Papers

Citing Papers