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Precision modification of heart failure signaling by CRISPR-Cas9 base editing
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DOI：10.1016/j.yjmcc.2026.06.008.png)
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Abstract
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• Base editing enables precise signaling modification for heart failure therapy. • Base editing of PKCα T497 induces protein degradation and confers cardioprotection. • Advanced delivery methods are crucial for clinical translation to adult hearts.
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