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Precision targeting of CLDN18.2: A new therapeutic paradigm for gastric cancer
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DOI:10.1016/j.ctrv.2026.103176.png)
Abstract
En 中文
• CLDN18.2 as a novel therapeutic target in gastric cancer. • mAbs show promising efficacy in CLDN18.2-positive gastric cancer. • ADCs improve targeted drug delivery to CLDN18.2-expressing cells. • Bispecific antibodies and CAR-T therapies broaden CLDN18.2-directed options. • Resistance and toxicity remain key challenges in CLDN18.2 targeting.
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