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Preclinical evaluation of nitrated α-synuclein-specific CAR-Treg therapy in Parkinson’s disease
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DOI：10.1016/j.xcrm.2026.102983.png)
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Abstract
En 中文
• An anti-nitrated α-synuclein antibody detects higher signal in PD serum • Serum anti-nitrated α-synuclein signal correlates with PD stage • Nitrated α-synuclein-specific CAR-Treg improve motor function • CAR-Treg reduce brain pathology and striatal Iba1-high myeloid-cell abundance
Keywords:
chimeric antigen receptor
α-synuclein pathology
neo-antigens
Parkinson’s disease mouse models
T cells
neuroinflammation
nitrated α-synuclein
neurodegeneration
immunotherapy
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