Prediction of perioperative FLOT outcomes in Resectable Gastric and GEJ Adenocarcinoma with pathologic and molecular features: A Retrospective Real-World Cohort Study

2026-07-11

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Annamaria Agnes

Laura Lorenzon *

Pasquale Moretta

Antonia Strippoli

Carmelo Pozzo

Riccardo Ricci

Flavio Tirelli

Lorenzo Ferri

L. La Rocca

Francesca Chicchi

Domenico D’Ugo

Giampaolo Tortora

Roberto Persiani

Alberto Biondi

DOI：10.1016/j.ejso.2026.112001

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Perioperative FLOT is the reference regimen for resectable gastric and gastroesophageal junction (GEJ) adenocarcinoma, yet predictors of response and survival remain incompletely defined. We evaluated pathological response, molecular associations, and survival in a real-world cohort from a high-volume Italian institution, with the aim of benchmarking contemporary outcomes and generating hypotheses for future risk stratification.

Prediction of perioperative FLOT outcomes in Resectable Gastric and GEJ Adenocarcinoma with pathologic and molecular features: A Retrospective Real-World Cohort Study

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