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Preoperative low C-reactive protein-albumin-lymphocyte (CALLY) index is a poor prognostic indicator for overall survival in patients undergoing surgery for pancreatic ductal adenocarcinoma
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DOI：10.1007/s00595-026-03270-8.png)
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Abstract
En 中文
Purpose This study aimed to investigate the prognostic impact of preoperative indicators that reflect systemic inflammatory, nutritional, and immune status, focusing on the C-reactive protein-albumin-lymphocyte (CALLY) index in patients undergoing surgery for pancreatic ductal adenocarcinoma. Methods This retrospective study included 120 patients (stage I = 19, II = 94, III = 7) who underwent surgical resection for pancreatic ductal adenocarcinoma between 2007 and 2019. Preoperative laboratory data and the CALLY index were collected to evaluate their impact on overall survival (OS). A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cutoff values. Results The optimal cutoff value for the preoperative CALLY index was 4.0. Patients with a low CALLY index (< 4.0) demonstrated a significantly worse OS than those with a high CALLY index (>= 4.0) (P = 0.001). A multivariate analysis of composite indices identified low CALLY index (P = 0.001) as an independent prognostic factor, along with positive lymph node metastasis (P = 0.035) and the absence of adjuvant chemotherapy (P = 0.005). Conclusion The CALLY index reflects the preoperative systemic inflammatory, nutritional, and immune status. It is a convenient and practical prognostic predictor of OS in patients undergoing surgery for pancreatic ductal adenocarcinoma.
Keywords:
Pancreatic cancer
Surgery
Overall survival
CALLY index
Biomarker
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