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Preparation, antioxidant, and antibacterial activities of cationic inulin derivative via azide-alkyne click reaction and N-methylation
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DOI：10.1016/j.ijbiomac.2026.152465.png)
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Abstract
En 中文
Cationic modification has been regarded as an effective tool for enhancing the bioactivity of inulin. In this study, cationic inulin derivative functionalized with 1,2,3-triazolium and pyridinium groups was designed and synthesized through the portfolio strategy of azide-alkyne click reaction and N-methylation. The structural elucidation of inulin derivatives was accomplished through Fourier transform infrared spectroscopy, nuclear magnetic resonance, zeta potential, thermal stability and solubility. The antioxidant potential was evaluated using radicals scavenging assays and reducing power assay. Meanwhile, in vitro antibacterial activity was assessed using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods against S. aureus, E. coli, and five types of gram-negative marine bacteria. The biological results showed that the introduction of 1,2,3-triazole and pyridine groups endowed moderate antioxidant and antibacterial activities of inulin. Moreover, the generation of 1,2,3-triazolium and pyridinium moieties by N-methylation further enhanced antioxidant capacity and amplified antibacterial activity, exhibiting MIC values of 0.0156–0.0312 kg/m3 and MBC values of 0.0312–0.0625 kg/m3 against S. aureus and E. coli. Besides, the biosafety was also assessed by the hemolysis and cytotoxicity assays, the experimental results showed that prepared inulin derivatives displayed benign biocompatibility with no obvious hemolytic activity and low cytotoxic effect toward L929 cells within the tested concentration range. Altogether, the multifunctionality and simple synthesis of cationic inulin derivative bearing 1,2,3-triazolium and pyridinium groups made it highly desirable for effectively preventing the infection from reactive radical and harmful bacteria, offering novel alternative for the development of novel antioxidant and antibacterial agents in medicine and food fields.
Keywords:
cationic inulin derivative
1,2,3-triazolium
pyridinium
antioxidant activity
antibacterial activity
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8.5
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21.7W
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