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Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent
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DOI：10.1016/j.jaci.2024.02.019.png)
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Abstract
En 中文
Background: Despite the promise of oral immunotherapy (OIT) to treat food allergies, this procedure is associated with potential risk. There is no current agreement about what elements should be included in the preparatory or consent process. Objective: We developed consensus recommendations about the OIT process considerations and patient-specific factors that should be addressed before initiating OIT and developed a consensus OIT consent process and information form. Methods: We convened a 36-member Preparing Patients for Oral Immunotherapy (PPOINT) panel of allergy experts to develop a consensus OIT patient preparation, informed consent process, and framework form. Consensus for themes and statements was reached using Delphi methodology, and the consent information form was developed. Results: The expert panel reached consensus for 4 themes and 103 statements specific to OIT preparatory procedures, of which 76 statements reached consensus for inclusion specific to the following themes: general considerations for counseling patients about OIT; patient- and family -specific factors that should be addressed before initiating OIT and during OIT; indications for initiating OIT; and potential contraindications and precautions for OIT. The panel reached consensus on 9 OIT consent form themes: benefits, risks, outcomes, alternatives, risk mitigation, difficulties/challenges, discontinuation, office policies, and longterm management. From these themes, 219 statements were proposed, of which 189 reached consensus, and 71 were included on the consent information form. Conclusion: We developed consensus recommendations to prepare and counsel patients for safe and effective OIT in clinical practice with evidence -based risk mitigation. Adoption of these recommendations may help standardize clinical care and improve patient outcomes and quality of life. (J Allergy Clin Immunol 2024;153:1621-33.)
Keywords:
Allergy
anaphylaxis
Delphi
food allergy
oral immu- notherapy
consent
patient preparation
shared decision making
risk mitigation
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