prepIMS: a Robust Data Preprocessing Workflow for Ion Mobility Mass Spectrometry Imaging

doi:10.1016/j.aca.2025.344951

prepIMS: a Robust Data Preprocessing Workflow for Ion Mobility Mass Spectrometry Imaging

2025-11-28

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DOI：10.1016/j.aca.2025.344951

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• prepIMS enhances peak detection accuracy in noise-affected ion mobility signals using a density cluster-based strategy. • prepIMS effectively separates isomeric and isobaric ions within the same mass peak, validated with simulation dataset and MALDI-TIMS dataset. • prepIMS promotes spatial segmentation in 4D IM-MSI data, supporting comprehensive molecular profiling in complex biological systems.

prepIMS: a Robust Data Preprocessing Workflow for Ion Mobility Mass Spectrometry Imaging

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