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Prereplication-complex formation: a molecular double take?
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DOI：10.1038/nsmb.2738.png)
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Abstract
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In G1, two copies of the MCM2-7 helicase are recruited to each origin of replication. Whereas recruitment of the first MCM2-7 is likely to be analogous to the loading of sliding clamps around DNA, how the second MCM2-7 complex is recruited is highly contentious. Here, we argue that MCM2-7 loading involves specific modifications to the clamp-loading reaction and propose that the first and second MCM2-7 molecules are loaded via similar mechanisms.
Keywords:
ORIGIN RECOGNITION COMPLEX
REPLICATIVE DNA HELICASE
ATPASE ACTIVITY
MCM2-7 HELICASE
BUDDING YEAST
ORC
BINDING
PROTEIN
LOADER
CDT1
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