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Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
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DOI：10.1038/s41598-020-65377-3.png)
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Abstract
En 中文
The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120h after death, expanding the availability and use of human diseased tissue stored in brain banks.
Keywords:
GABA(A) RECEPTORS
XENOPUS OOCYTES
MICROTRANSPLANTATION
BRAIN
PLASTICITY
EXPRESSION
ADULT
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