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Presynaptic SNAP25 supports maturation of hippocampal mossy fiber-CA3 synapses
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DOI：10.1016/j.isci.2026.116503.png)
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Abstract
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• SNAP25 is dispensable for mossy fiber targeting in the hippocampus • SNAP25-deficient mossy fiber boutons fail to mature in postnatal development • Presynaptic SNAP25 loss impairs postsynaptic thorny excrescence formation • Loss of SNAP25 leads to abnormal synaptic vesicle accumulation in adults
Keywords:
molecular neuroscience
cellular neuroscience
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