.png){kind=icon}
.png){kind=icon}
Return
Prevalence and β-Lactam Resistance of Enterobacterales Isolated from Urinary Samples in a Regional Hospital in Poland: Special Emphasis on Elderly Population
.png){kind=icon}
OA
AI
Ł
P
P
P
E
DOI：10.3390/pathogens15080840.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide. The growing prevalence of antimicrobial resistance among Enterobacterales, particularly to β-lactam antibiotics, contributes to treatment failures and prolonged hospital stays. This single-center descriptive surveillance study aimed to evaluate the distribution of Enterobacterales recovered from culture-positive urine samples in the Provincial Specialist Hospital in Włocławek, Poland, and to determine the prevalence of β-lactam resistance phenotypes among these isolates. Urine culture results collected between January and December 2025 from all hospital wards and the outpatient urology clinic were retrospectively analyzed in this study, with 1090 positive urine cultures included. For a subset of 85 isolates, microbiological findings were additionally linked with patients’ clinical characteristics. Bacteria of the genus Escherichia were the most frequently isolated (53.8%), followed by Klebsiella (22.9%) and Proteus (14.2%), with the remaining Enterobacterales genera recovered at frequencies ranging from 0.6% to 4.5%. Most isolates presented no detectable β-lactam resistance phenotype; however, resistance mediated by β-lactamase production was observed in some of them. Phenotypic ESBL and AmpC producers accounted for 25.3% and 0.6% of isolates, respectively, whereas phenotypic carbapenemase-producing strains were detected less frequently, with MBL and KPC producers representing 1.4% and 0.3% of isolates, respectively. No clear associations were identified between patient characteristics and the occurrence of specific bacterial isolates or resistance mechanisms, which may be explained by the relatively homogeneous study population, the majority of whom were ≥70 years old (66/85; 77.6%) and had a similar burden of comorbidities. In conclusion, the current level of β-lactam resistance phenotypes among urinary Enterobacterales in our setting can be considered moderate. Nevertheless, continuous surveillance of local urine-derived bacteria and their antimicrobial resistance profiles remains essential for optimizing effective control strategies.
Keywords:
Enterobacterales
antibiotic resistance
β-lactams
prevalence
Journal
IF:
3.3
Papers:
9.4K
Citations:
2.3W
Organization
Cited Papers