Prevalence, symptom architecture, and clinical correlates of depressive and anxiety symptoms in bipolar disorder: A large-scale community-based study

Yuyin Zhang

doi:10.1016/j.jad.2026.122357

Prevalence, symptom architecture, and clinical correlates of depressive and anxiety symptoms in bipolar disorder: A large-scale community-based study

2026-08-05

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PRE

AI

Y

Yuyin Zhang

J

Jingsong Ma

Y

Yue Wu

M

Mingjin Luo

H

Haopeng Wu

H

Haidong Song *

X

Xiaohua Sun *

M

Mingzhe Zhao *

DOI：10.1016/j.jad.2026.122357

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• Residual depression and anxiety symptoms form a tightly interconnected network in BD. • Psychomotor alterations, guilt, and worry emerge as the most central network nodes. • Motor, irritability, and fear act as bridge features driving cross-domain anxiety. • Poor social support and sleep disturbances correlate heavily with affective clusters.

Prevalence, symptom architecture, and clinical correlates of depressive and anxiety symptoms in bipolar disorder: A large-scale community-based study

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