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Primary Tumor-Associated Loss of the Y Chromosome and Clinical Outcome in Metastatic Colorectal Cancer
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DOI：10.1002/gcc.70147.png)
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Abstract
En 中文
Alterations of the Y chromosome are frequent events in solid tumors, yet their biological and clinical significance remains incompletely understood. In colorectal cancer (CRC), recent studies have suggested context-dependent roles of Y-linked genes in tumor progression, while the impact of tumor-associated loss of the Y chromosome (LoY) in metastatic disease has not been clearly established.
Keywords:
biomarker
chromosomal instability
colorectal cancer
KRAS
loss of Y chromosome
survival
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