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Primed to squeeze: mechanical memory in confined migration
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DOI：10.1016/j.tcb.2026.06.008.png)
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Abstract
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Do cells remember past mechanical experiences to prepare for future physical challenges? Holle et al. demonstrate that stiffness priming enhances confined migration through NFATC2-dependent programs. Beyond this specific mechanism, their work supports the emerging concept of mechanical memory as a hierarchy of interconnected cellular states operating across multiple timescales.
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