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Pro-Xylane alleviates ultraviolet-induced skin senescence through SGK1-mediated p21 ubiquitination and subcellular translocation
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DOI：10.1016/j.mad.2026.112194.png)
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Abstract
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• Pro-Xylane enhances cell viability, reduces apoptosis, and inhibits reactive oxygen species (ROS) production in UVB-irradiated HaCaT cells, while also reversing UVB-induced upregulation of senescence markersand senescence-associated secretory phenotype (SASP) levels. • SGK1 is confirmed as a critical target mediating Pro-Xylane’s protective effects against UVB-induced skin damage. • Pro-Xylane exerts its anti-senescence function by promoting ubiquitination of p21 at the K141 site and retaining p21 in the cytoplasm, which counteracts UVB-induced accumulation of p21 in the nucleus. • In vivo experiments using UVB-irradiated rats confirm Pro-Xylane’s ability to support skin regeneration, highlighting its promising role as a candidate for skin repair and anti-aging treatments.
Keywords:
Pro-Xylane
UVB
Skin senescence
SGK1
Ubiquitination
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