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Probing metabolic integration in obligate, intracellular symbioses
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DOI：10.1016/j.cois.2026.101541.png)
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Abstract
En 中文
• spatially and temporally resolved imaging and OMICS techniques describe host-symbiont integration • metabolic modelling based on integrated OMICS data allows for establishing detailed hypotheses on host-symbiont interactions • experimental and genetic manipulation is becoming increasingly available for non-model insects and unculturable microorganisms • pharmacological inhibition can modulate individual enzymatic reactions • labelling approaches allow to follow the fate of specific metabolites • in combination these approaches allow to decipher mechanisms of physiological integration
Keywords:
metabolic integration
host-symbiont interactions
OMICS techniques
metabolic modelling
pharmacological inhibition
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