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delete2019-12-09
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PRE
AI
M
Michael A. Erb *
DOI:10.1038/s41589-019-0428-xdelete
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Abstract

Abstract

En 中文
Phenotypic screening is an engine of discovery for bioactive small molecules and can unravel novel mechanisms and pathways controlling cellular physiology. A recent study reveals the CPSF complex as a pharmacologically tractable target of JTE-607 and context-specific cancer dependency.
Keywords:
INHIBITOR
JTE-607
TRANSCRIPTION
ENDOTOXIN

Journal

Nature Chemical Biology cover
Nature Chemical Biology
IF:
13.7
Papers:
4.8K
Citations:
3.9W

Organization

S
Scripps Research Institute
Scholars:
764
Papers: 193
Citations: 2.2K
Cited Papers

Cited Papers

Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers
err2011-11-01
err8
PREAI
errBorozdenkova, Svetlana; Mant, Timothy G. K.; Allen, Elizabeth; Pu, Kewei; Hoshino, Shoji; Jurcevic, Stipo
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CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma
err2019-12-09
err70
errOAAI
errRoss, Nathan T.; Lohmann, Felix; Carbonneau, Seth; Fazal, Aleem; Weihofen, Wilhelm A.; Gleim, Scott; Salcius, Michael; Sigoillot, Frederic; Henault, Martin; Carl, Sarah H.; Rodriguez-Molina, Juan B.; Miller, Howard R.; Brittain, Scott M.; Murphy, Jason; Zambrowski, Mark; Boynton, Geoffrey; Wang, Yuan; Chen, Aye; Molind, Gregory J.; Wilbertz, Johannes H.; Artus-Revel, Caroline G.; Jia, Min; Akinjiyan, Favour A.; Turner, Jonathan; Knehr, Judith; Carbone, Walter; Schuierer, Sven; Reece-Hoyes, John S.; Xie, Kevin; Saran, Chitra; Williams, Eric T.; Roma, Guglielmo; Spencer, Matt; Jenkins, Jeremy; George, Elizabeth L.; Thomas, Jason R.; Michaud, Gregory; Schirle, Markus; Tallarico, John; Passmore, Lori A.; Chao, Jeffrey A.; Beckwith, Rohan E. J.
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Pharmacological Modulation of Transcriptional Coregulators in Cancer
err2019-06-01
err12
errOAAI
errBishop, Timothy R.; Zhang, Yuxiang; Erb, Michael A.
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Group-based local adaptive deep multiple kernel learning with lp norm
err2020-09-17
err0
errOAAI
errShengbing Ren; Fa Liu; Weijia Zhou; Xian Feng; Chaudry Naeem Siddique
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