Processing Technologies for 3D Nanostructured Tissue Engineering Scaffolds

Decheng Meng

doi:10.1002/adem.201080019

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Processing Technologies for 3D Nanostructured Tissue Engineering Scaffolds

2010-09-08

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Decheng Meng *

M. Erol

Aldo R. Boccaccini

DOI：10.1002/adem.201080019

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Abstract

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Engineered scaffolds made from synthetic or natural biomaterials are crucial elements in tissue engineering strategies. Numerous biomaterials are being used to fabricate scaffolds, including glasses, ceramics, metals, polymers, and their composites. Although materials chemistry and scaffold architecture (pore size, pore volume) are important factors affecting cell-surface interactions, the roughness and topography of the scaffold surface plays an essential part too, especially nanoscale features are relevant. Extensive research has been carried out on introducing nanoscale features on 2D, flat surfaces, but much limited efforts have been focused on nanostructuring the surface of 3D scaffolds. This paper specifically reviews the current techniques that are available to introduce or engineer nanoscale topography on the surfaces of 3D scaffolds or on 2D surfaces that can be successfully assembled into 3D scaffolds via post-processing. The literature reviewed provides evidence about the influence of nanoscale topography on cell attachment, migration, and proliferation. While the paper is focused on bone tissue scaffolds, several technologies reviewed are equally applicable to scaffolds suitable for engineering and regeneration of other tissues.

Keywords:

PEPTIDE-AMPHIPHILE NANOFIBERS

MESENCHYMAL STEM-CELLS

POLY(L-LACTIC ACID) SCAFFOLDS

IRON-OXIDE NANOPARTICLES

CARBON NANOTUBE MWCNT

COMPOSITE SCAFFOLDS

ELECTROPHORETIC DEPOSITION

SURFACE MODIFICATION

POROUS SCAFFOLDS

IN-VITRO

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