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Prognostic Value of 15O-Water PET Global Myocardial Flow Reserve: Proposed Risk-Based Cutoffs
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DOI：10.1016/j.nuclcard.2026.102795.png)
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Abstract
En 中文
A global myocardial flow reserve (MFR) threshold of 2.5 is clinically used to define normal vasodilatory capacity with 15O-water PET myocardial perfusion imaging but lacks prognostic validation. Since mean global MFR exceeds 3.5 in healthy individuals, the 2.5–3.5 range may represent an intermediate-risk “gray zone”. We aimed to evaluate a 4-tiered global MFR categorization for risk stratification.
Keywords:
myocardial flow reserve
positron emission tomography
15O-water
chronic coronary syndromes
prognosis
risk stratification
CCS
Chronic coronary syndromes
MACE
Major adverse cardiac events
MBF
Myocardial blood flow
MFR
Myocardial flow reserve
MVD
Microvascular dysfunction
PET
Positron emission tomography
RPP
Rate-pressure product
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