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Programmable tissue-adhesive hydrogels with temporal and spatial selectivity
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DOI：10.1039/D4CS01297F.png)
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Abstract
En 中文
With the expanding application of hydrogels in the biomedical filed; tissue-adhesive hydrogels (TAHs) have emerged as a critical focus of research. Unlike conventional adhesives; achieving effective tissue adhesion requires a sophisticated strategy that addresses the challenges posed by the complex biological microenvironment. Critical considerations in hydrogel design include the dynamic wet environment in vivo; spatiotemporally controlled adhesion; and asymmetric interfacial interactions. These properties cannot be attained through universal solutions but require customized design frameworks integrating multi-scale engineering principles. Recent advances have systematically optimized hydrogel adhesion through integrating multi-scale design principles: microscale mechanisms of physical/chemical interactions; molecular-scale modifications such as hydrophobic chain segments and topological entanglements; and macroscale structural patterning. Driven by advancements in polymer science; materials science; and biomedical engineering; the development of TAHs has evolved from single-function adhesion enhancement to the rational design of multifunctional bioactive adhesive systems with programmable adhesion across multiple dimensions. This review provides a comprehensive overview of current advancements in TAHs; identifies key challenges in clinical translation; and proposes future directions to bridge fundamental discoveries with practical biomedical applications.
Journal
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39
Papers:
629
Citations:
18.4W
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