.png){kind=icon}
.png){kind=icon}
Return
Programming Affinity for Precise Tumor Recognition with Allosteric Nanosensing-Circles
.png){kind=icon}
PRE
AI
DOI：10.1021/acsnano.3c01709.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Although many smart probes for precise tumor recognitionhave beenreported, the challenge of on-target, off-tumor remains.Therefore, we herein report the fabrication of a series of allostericallytunable DNA nanosensing-circles (NSCs). The recognition affinity ofNSCs is programmed through sensitivity to tumor microenvironment (TME)hallmarks such as small molecules, acidity, or oncoproteins. Becauseof their special programming conditions and active targeting capabilities,NSCs can overcome the obstacles noted above, thus achieving precisetumor recognition. Results from in vitro analysisdemonstrated that NSCs obtain their recognition ability through allostericregulation after sensing TME hallmarks. Furthermore, in vivo imaging indicated that NSCs enable precise tumor imaging. Theseresults demonstrate that our NSCs will be promising tools for precisetumor imaging and therapy.
Keywords:
precise tumor recognition
tumor microenvironment
DNA nanostructure
aptamer
allosteric regulation
Journal
IF:
16
Papers:
2.6W
Citations:
25.6W