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Programming DNA Self-Assembly by Geometry
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DOI：10.1021/jacs.2c02456.png)
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Abstract
En 中文
This manuscript introduces geometry as a means to program the tile-based DNAself-assembly in two and three dimensions. This strategy complements the sequence-focusedprogrammable assembly. DNA crystal assembly critically relies on intermotif, sticky-end cohesion,which requires complementarity not only in sequence but also in geometry. For DNA motifs toassemble into crystals, they must be associated with each other in the proper geometry andorientation to ensure that geometric hindrance does not prevent sticky ends from associating. ForDNA motifs with exactly the same pair of sticky-end sequences, by adjusting the length (thus,helical twisting phase) of the motif branches, it is possible to program the assembly of these distinct motifs to either mix with oneanother, to self-sort and consequently separate from one another, or to be alternatingly arranged. We demonstrate the ability toprogram homogeneous crystals, DNAalloycrystals, and definable grain boundaries through self-assembly. We believe that theintegration of this strategy and conventional sequence-focused assembly strategy could further expand the programming versatility ofDNA self-assembly
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