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Progranulin as a context-dependent regulator of innate immunity in bacterial infections
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DOI：10.1016/j.cyto.2026.157176.png)
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Abstract
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• Clinical application of progranulin requires understanding its disease and context specific functions. • Progranulin exerts anti-inflammatory effects that may compromise antimicrobial immune signaling. • Progranulin modulates TNF-α signaling and macrophage polarization during bacterial infection. • In tuberculosis, progranulin may influence the balance between pathogen control and immunopathology.
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