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Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial

delete2026-07-06
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OA
AI
W
Wolfgang Hitzl *
T
Tiago Lerda-Casaccia
M
Michael Unterhofer
R
Rina Demjaha
M
Maria Martinez-Serrat
M
Michael Khalil
A
Andrea Harrer
B
Belinda Böhm
P
Peter Hofbauer
J
Janne Cadamuro
U
Ursula Huber-Schönauer
E
Eugen Trinka
DOI：10.1093/brain/awag099delete
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Abstract

Abstract

En 中文
Propionic acid (PA), a microbial-derived short-chain fatty acid, contributes to intestinal barrier integrity, systemic immune regulation, and neuronal function. Individuals with multiple sclerosis show reduced PA levels, and open-label data have suggested beneficial immunomodulatory and clinical effects of supplementation.

Journal

Brain cover
Brain
IF:
11.7
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1.4W
Citations:
6.3W

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S
Salzburg University of Applied Sciences
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20
Papers: 13
Citations: 228
M
Medical University of Graz
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1.4W
Papers: 9.8K
Citations: 1.2W
L
landesapotheke salzburg
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2
Papers: 1
Citations: 0
P
Paracelsus Medical University
Scholars:
481
Papers: 175
Citations: 4.9K
P
paracelsus medical university salzburg
Scholars:
13
Papers: 9
Citations: 0
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