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PROTAC-ing tuberculosis
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DOI：10.1038/s41589-024-01624-2.png)
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Abstract
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Targeted protein degradation has emerged as a promising approach in drug discovery, harnessing a cell's intrinsic machinery to eliminate disease-related proteins. Now, a study paves the way to translating this technology into potential anti-mycobacterial therapies, by exploiting the bacterial protein-degradation complex.
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FEBS JOURNAL
OAAI
FEBS JOURNALIF4.2
OAAIShareSaveHomo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradationNATURE COMMUNICATIONSOAAI
NATURE COMMUNICATIONSIF15.7
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