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Protective effect of obeticholic acid on cyclophosphamide-induced thyroid toxicity in rats by inhibiting TXNIP/NLRP3/ASC/caspase-1-dependent pyroptosis and p53/BAX/caspase-3-dependent apoptosis
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DOI：10.1016/j.biopha.2025.118894.png)
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Abstract
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• The study revealed protective effect of obeticholic acid in thyroid injury. • Cyclophosphamide can cause thyroid injury. • Thus depends on inhibiting TXNIP/NLRP3/ASC/caspase1 - dependent pyroptosis and p53/BAX/ caspase 3 -dependent apoptosis • The role of oxidative stress, inflammation and apoptosis was evident.
Keywords:
Cyclophosphamide
Obeticholic acid
Thyroid toxicity
Oxidative stress
Inflammation
Pyroptosis
Apoptosis
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