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Protective effects of Jiao-Ai Decoction against progesterone withdrawal-induced pregnancy loss: Insights from rat model assays, bioactive component analysis, molecular simulation, and zebrafish angiogenesis evaluation

delete2026-08-11
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PRE
AI
X
Xinru Hu
J
Jiaqi Yun
J
Jia Deng
C
Chen Liu
X
Xueyu Niu
J
Jialin Gao
Y
Yuechun Lu
H
Han Ou
Z
Ziqi Wang
T
Ting Geng *
Y
Yi Zhang *
张丽 cover
张丽 (Zhang Li) *
DOI：10.1016/j.jep.2026.122290delete
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Abstract

Abstract

En 中文
• JAD reduces embryo loss, modulates uterine hemodynamics and angiogenesis, with suppressed HIF‑1α and elevated VEGFA/p‑VEGFR2. • JAD boosts endometrial receptivity alongside higher pinopode density and receptivity marker levels. • Core constituents of JAD such as paeoniflorin and glycyrrhizic acid stably bind FLT1 and VWF. • JAD and its representative components exert pro-angiogenic and hemostatic effects in zebrafish without toxicity.

Journal

Journal of Ethnopharmacology cover
Journal of Ethnopharmacology
IF:
5.4
Papers:
2.6K
Citations:
6.2W

Organization

N
nanjing university of chinese medicine
Scholars:
1.8W
Papers: 9.1K
Citations: 14
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