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Protective effects of okra (Abelmoschus esculentus (L.) Moench) seed extract against acute and chronic UV-induced skin damage, implicating PLD-associated lipid signaling
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DOI：10.1016/j.jphotobiol.2026.113390.png)
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Abstract
En 中文
Ultraviolet (UV) radiation is a major environmental factor driving skin photoaging and dermal injury, with implications for cutaneous function and appearance. In this study, the protective potential of okra (Abelmoschus esculentus (L.) Moench) seed extract against UVA/UVB-induced skin damage was investigated, integrating network pharmacology, in vitro cell assays, in vivo mice models, and metabolomic profiling to explore potential mechanisms. LC-MS/MS analysis identified ten major bioactive compounds in the okra seed extract, including 10-nitro-9E-octadecenoic acid, 9 s,13r-12-oxophytodienoic acid, octadecanedioic acid among others. In vitro, okra seed extract showed low cytotoxicity and promoted HaCaT cell proliferation and migration. In both acute and chronic UV exposure mouse models, treatment with okra seed extract markedly alleviated epidermal thickening and dermal collagen disruption, was associated with normalization of UV-induced alterations in COL1 and COL3 expression, and attenuated UV-associated increases in MMP3 levels. Mechanistically, integrated metabolomic and network pharmacology analyses suggested the involvement of PLD-associated lipid signaling, accompanied by alterations in lipid metabolites. Collectively, these findings highlight okra seed extract as a promising plant-derived photoprotective agent, providing mechanistic insight and supporting its potential translation into interventions for skin health preservation.
Keywords:
Okra seed extract
Photoaging
UV radiation
Skin photoprotection
PLD/PI3K-Akt signaling
Lipid metabolite
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