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Protein Lactylation in Liver Disease: A Comprehensive Review
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DOI：10.1017/erm.2026.10036.png)
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Abstract
En 中文
BackgroundLactate; generated through glycolysis; plays a dual role as both a metabolic substrate and a signalling molecule; influencing cellular functions in pathophysiological scenarios. Protein lactylation; a recently identified form of post-translational modification mediated by lactate; has garnered significant and increasing attention. Globally; hepatic disorders pose a significant public health burden; frequently involving disruptions in glucose metabolism and consequent lactate buildup.MethodsThis comprehensive review examines the discovery; regulatory mechanisms and pathogenic roles of lactylation in diverse liver disorders; while critically evaluating emerging lactylation-targeted therapeutics to guide future translational research.ResultsLactylation modifications play a pivotal role in various pathophysiological processes; including hepatic inflammation; liver fibrosis; ischaemic injury; tumour growth and metastasis.ConclusionsModulation of lactylation pathways; coupled with pharmacological control of lactate synthesis and shuttling; emerges as a strategic approach to liver disease therapeutics.
Keywords:
lactate
lactylation
liver disease
pharmacology
post-translational modification
treatment
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