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Proteomic responses to acute sesamolin exposure in zebrafish embryos
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DOI：10.1016/j.cbpc.2025.110322.png)
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Abstract
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• Sesamolin induces developmental abnormalities in zebrafish embryos, such as yolk sac edema, spinal curvature, blood clots, and defects in erythropoiesis. • Sesamolin downregulates the expression of several proteins, including vitellogenins, ribosomal proteins, cytoskeletal proteins, heat shock proteins, hemoglobin proteins, and ATP synthase. • The toxicity of sesamolin stems from its impact on the expression of proteins involved in development, cell structure, and metabolic processes.
Keywords:
sesamolin
zebrafish embryos
developmental abnormalities
protein expression
toxicity
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