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Proteomics and human microchips identify Thrombospondin-1 as a potential biomarker for calciphylaxis stem cell therapy

delete2026-06-19
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OA
AI
J
Jiaying Hu
S
Shijiu Lu
L
Lianju Qin
Y
Yaoting Sun
X
Xiaoxue Ye
Q
Qinyi Lin
J
Jing Zhang
M
Ming Zeng
J
Jingjing Wu
K
Kang Liu
J
Jingfeng Zhu
L
Ling Zhang
F
Feng Chen
Z
Zaozao Chen
S
Shihui Xu
Z
Zhangzhi Xue
Y
Yongwu Yu
L
Lu Li
W
Weigang Ge
Z
Zhongze Gu
DOI：10.1016/j.isci.2026.116388delete
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Abstract

Abstract

En 中文
• THBS1 and TGF-β1 are promising blood biomarkers for calciphylaxis • hAMSCs reduce blood THBS1/TGF-β1 levels and improve skin lesions in calciphylaxis patients • THBS1/TGF-β1 signaling underlies microvascular injury and thrombosis in calciphylaxis • hAMSCs repair microvascular injury in a human chip model of calciphylaxis
Keywords:
Health sciences
Medicine
Proteomics

Journal

iScience cover
iScience
IF:
4.1
Papers:
4.6K
Citations:
4.1W

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