Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α–stimulated ARPE-19 cells

2026-06-20

PRE

Xi Chen

Meilin Liao

Ruifang Han

Juan Gao

Ping Lu

Liming Wang

Xiaomin Zhang

Xuan Li *

DOI：10.1016/j.intimp.2026.117048

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• Apigenin attenuates TNF-α–induced inflammation in ARPE-19 cells. • Apigenin selectively suppresses NF-κB and MAPK signaling pathways. • Proteomics reveals global changes in inflammation-related proteins. • Key proteins linked to immune response and stress are regulated. • Apigenin shows potential for treating retinal inflammatory diseases.

Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α–stimulated ARPE-19 cells

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