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Proteostasis driven redox adaptation in ferroptosis: the p62-Keap1-Nrf2 axis

delete2026-06-04
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PRE
AI
N
Nilufer Ercin
M
Merve Beker
N
Nail Besli
U
Ulkan Celik *
DOI：10.1016/j.pbiomolbio.2026.05.007delete
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Abstract

Abstract

En 中文
• Proteostasis disruption shapes cellular susceptibility to ferroptosis. • p62-Keap1-Nrf2 axis links autophagy, redox balance, and ferroptosis. • Redox buffering shifts the ferroptotic threshold under stress. • p62 functions as an adaptor of proteostasis rather than a direct executor of ferroptosis. • Context-dependent effects differ between cancer and neuronal cells.

Journal

Progress in Biophysics and Molecular Biology cover
Progress in Biophysics and Molecular Biology
IF:
4.5
Papers:
1.8K
Citations:
4.7K

Organization

I
istanbul atlas university
Scholars:
204
Papers: 150
Citations: 0
U
university of health sciences
Scholars:
1.6K
Papers: 545
Citations: 0
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