.png){kind=icon}
.png){kind=icon}
Return
Pseudohypoxia induced by chemical pollutants: Biochemical evidence of environmental vulnerability
.png){kind=icon}
OA
AI
DOI：10.1016/j.ecoenv.2025.119243.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Innovative concept introduction: The study pioneers the concept of "pollutant-induced pseudohypoxia" and elucidates its mechanism, providing a novel perspective for pollutant toxicity research. • Comprehensive review of pollutant-HIF-1α interactions: This work reveals the diversity and complexity of the mechanisms by which various environmental pollutants (e.g., heavy metals, organic pollutants, atmospheric particles) induce pseudohypoxia. • Interdisciplinary research and clinical significance: Integrating multidisciplinary perspectives from molecular biology, toxicology, epidemiology, and clinical medicine, this study examines the role of pollutants in pseudohypoxia and their impact on cancer, cardiovascular, and neurodegenerative diseases. • Future research directions and challenges: The article points out the research limitations and clinical diagnosis and treatment challenges of pollutant-induced pseudohypoxia, providing valuable reference directions for future investigations.
Keywords:
AD
Alzheimer's disease
Al
Aluminum
ARNT
Aryl Hydrocarbon Receptor Nuclear Translocator HIF-1β/ARNT
As
arsenic
BaP
Benzo[a]pyrene
BPA
Bisphenol A
CCS
superoxide dismutase 1 copper chaperone
Cd
cadmium
Co
cobalt
COPD
chronic obstructive pulmonary disease
COX
cyclooxygenase
CPF
chlorpyrifos
Cr VI
hexavalent chromium
Cu
copper
DEHP
Di-2-ethylhexyl phthalate
DEPs
diesel exhaust particles
DSBs
double-strand DNA breaks
EGF
epidermal growth factor
EPO
erythropoietin
ERs
estrogen receptors
FIH1
Factor Inhibiting HIF-1
FLT1
fms-related tyrosine kinase 1
GLY
glyphosate
GSH
glutathione
HFpEF
heart failure with preserved ejection fraction
FA
formaldehyde
HIF-1α
hypoxia-inducible factor 1-alpha
HMs
heavy metals
HRE
hypoxia response element
IDH1
isocitrate dehydrogenase 1
LYC
lycopene
MAL
malathion
MDS
myelodysplastic syndrome
Mev
mevinphos
Mn
manganese
MnO₂
manganese dioxide
MPs
microplastics
NAD⁺
Nicotinamide adenine dinucleotide
NADH
Nicotinamide Adenine Dinucleotide Hydrogenated
Ni
nickel
NiNPs
nickel nanoparticles
O₃
ozone
PAHs
polycyclic aromatic hydrocarbons
PARP
polyADP-ribose polymerase
Pb
lead
PCBs
polychlorinated biphenyls
PCOS
polycystic ovary syndrome
PHDs
prolyl hydroxylases
PHCZ
polyhalogenated carbazole
PIGF
placental growth factor
PPGL
paraganglioma/pheochromocytoma
PQ
paraquat
PS-NPs
polystyrene nanoparticles
PVC
polyvinyl chloride
ROS
reactive oxygen species
RUNX3
Runt-related transcription factor-3
RVLM
rostral ventrolateral medulla
StAR
steroidogenic acute regulatory protein
SUMO
small ubiquitin-like modifier
TCDD
2,3,7,8-Tetrachlorodibenzo-p-dioxin
TEPA
tetraethylenepentamine
TET1
Ten-eleven translocation 1
UCHL1
ubiquitin C-terminal hydrolase L1
UV-B
ultraviolet radiation
VEGF
vascular endothelial growth factor
VHL
von Hippel–Lindau
VOCs
volatile organic compounds
P300
E1A binding protein p300
1368-BCZ
1,3,6,8-tetrabromo-9H-carbazole
Pseudohypoxia
Hypoxic response
Hypoxia
HIF-1α
Chemical pollutants
Environmental vulnerability
Heavy metals
Atmospheric particulate matter
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
E
IF:
6.1
Papers:
1.8W
Citations:
6.9W
Organization
View more organizations