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Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis
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DOI：10.1016/j.stem.2026.05.012.png)
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Abstract
En 中文
• Psychological stress induces aging-like dysfunction in HSCs • mPFC/PAG suppression impairs HSCs through sympathetic gut signaling • Stress reduces L. reuteri and spermidine to promote ferroptotic stress in HSCs • Spermidine restores autophagy and HSC function under psychological stress
Keywords:
hematopoietic stem cell
aging
metabolism
psychological stress
microbiota
intestinal environment
sympathetic pathway
spermidine
autophagy
lymphoid differentiation
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