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PTPN22 regulates T cell synapse formation through PSTPIP1-dependent actin remodeling
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DOI：10.1126/scisignal.ady6063.png)
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Abstract
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The protein tyrosine phosphatase PTPN22 suppresses T cell stimulation by acting on tyrosine-phosphorylated signaling molecules associated with the T cell receptor (TCR). Through super-resolution imaging analysis, Joseph et al. showed that PTPN22 also modulates T cell stimulation at the plasma membrane through its interaction with the cytoskeletal adaptor protein PSTPIP1. In PTPN22-deficient Jurkat cells, PSTPIP1 accumulated at TCRs, leading to excessive actin cytoskeletal remodeling, TCR clustering, and downstream signaling, which enhanced responses to low-affinity antigen. These findings highlight a pathway that may underlie aberrant T cell responses in autoimmunity. —John F. Foley
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