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Pulmonary cold sensing through Club cells triggers adipose thermogenesis to ameliorate obesity

delete2026-07-27
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PRE
AI
J
Junkun Jiang
C
Chengrui Liang
Z
Zelin Wang
Z
Zhangming Lu
W
Wenjing Yu
X
X L Wang
C
Chuan Zhang
张振宁 cover
张振宁 (Zhen‐Ning Zhang) *
栾
栾冰 (Bing Luan) *
DOI：10.1016/j.devcel.2026.07.003delete
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Abstract

Abstract

En 中文
• Pulmonary cold sensing promotes adipose thermogenesis • KCNK2 mediates cold-induced calcium signaling in Club cells • Cold-triggered calcium signaling enhances pulmonary FNDC5/Irisin production • Pharmacological activation of this pathway improves metabolic health in obese mice

Journal

Developmental Cell cover
Developmental Cell
IF:
8.7
Papers:
6.3K
Citations:
3.4W

Organization

T
tongji university
Scholars:
7.5W
Papers: 5.8W
Citations: 98
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