.png){kind=icon}
.png){kind=icon}
Return
Pulse instabilities can shape virus-immune coevolution
.png){kind=icon}
OA
AI
DOI：10.1103/PhysRevResearch.6.033300.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Adaptive immune systems engage in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of genetically varying strains that have already elicited a functional immune response. It has been argued that this dynamical process can lead to a propagating pulse of an ever-changing viral population and concomitant immune response. Here, we introduce a new stochastic model of viral-host coevolution, taking into account finite-sized host populations and varying processes of immune forgetting. Using both stochastic and deterministic calculations, we show that there is indeed a possible pulse solution, but for a large host population size and for finite memory capacity, the pulse becomes unstable to the generation of new infections in its wake. This instability leads to an extended endemic infection pattern, demonstrating that the population-level behavior of virus infections can exhibit a wider range of behavior than had been previously realized.
Keywords:
Bionanoparticles
Chitosan
Bactericidal
Anti-oxidant
Biosafety
Journal
IF:
4.2
Papers:
7.6K
Citations:
2.7W