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PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features
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DOI：10.1016/j.xgen.2026.101332.png)
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Abstract
En 中文
• Nano-Mod-Amp quantifies PUS7-dependent pseudouridines at targeted sites • PUS7-dependent pseudouridines range from low to high stoichiometry • Mutagenesis and ASOs show sequence and RNA structure guide modification by PUS7 • PUS7 activity is regulated by cell type and cellular context
Keywords:
pseudouridine
RNA modification
epitranscriptome
RNA structure
cell type regulation
PUS7
nanopore sequencing
antisense oligo
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