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PVA-GO-Lip hydrogel loaded alendronate sodium: friction adaptation, controlled release, antibacterial and mineralization mechanism
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DOI：10.1080/09205063.2025.2525505.png)
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Abstract
En 中文
This research developed an advanced polyvinyl alcohol (PVA) based hydrogel, which combines graphene oxide (GO) and liposome (Lip) to solve the key challenges in joint repair. PVA-GO-Lip composite material was prepared by freeze-thaw cycling, forming a composite structure with hydrogen bonding network and embedded Lip micro reservoir. This material has excellent mechanical properties (300% elongation, 4.2 kg load capacity) and self-healing properties through dynamic hydrogen bonding. Friction tests showed that compared to pure PVA, friction was reduced by 48% (coefficient: 0.11) due to GO enhanced hydration and Lip mediated boundary lubrication. The release of alendronate (ALN) follows Higuchi kinetics, with stable Lip release under mechanical stress (cumulative release 82.4%). GO has excellent antibacterial activity (inhibition rate > 98% againstEscherichia coliandStaphylococcus aureus), while ALN promotes significant mineralization (calcium/phosphate content increased by 8–16 times). This composite material has excellent stability (degradation of 2.6% within 30 days), adjustable hydrophilicity (contact angle of 36.5°), and swelling ability (equilibrium ratio of 49.21%). This multifunctional hydrogel combines mechanical durability, adaptive lubrication, controlled drug delivery, antibacterial effect and osteogenic potential. It is a promising biomimetic solution for the treatment of osteoarthritis and cartilage regeneration, linking biomechanical properties with therapeutic functions.
Keywords:
Hydrogel
oxidized graphene
liposomes
wear resistance
drug sustained release
antibacterial performance
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