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Pyridoxal 5-Phosphate Preserves Lens Biochemical and Structural Integrity in Experimental Cataract Formation
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DOI：10.1016/j.exer.2026.111048.png)
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Abstract
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• Pyridoxal 5 phosphate (PLP) attenuates sodium selenite–induced cataract in rat pups • PLP reduced the cataract incidence and lens opacity index • PLP increased the lens protein concentration and Na+/K+-ATPase activity • PLP reduces oxidative stress and lipid peroxidation (MDA) • PLP suppresses TNF-α, IL-1β, IL-6 and ameliorate antioxidant enzymes (S0D, CAT, and GSH). • PLP suppresses caspase-3 expression and shows anti-apoptotic effects in cataract effects
Keywords:
Pyridoxal 5-phosphate
cataract
oxidative stress
lens opacity
anti-apoptotic effects
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